32. Potent Sialylation Inhibitors Based on C-5 Modified Fluorinated Sialic Acids. Heise T., Pijnenborg J.F.A., Bull C., van Hilten N., Kers-Rebel E.D., Balneger N., Elferink H., Adema G.J.*, Boltje T.J.*, J. Med. Chem., 2018, 10.1021/acs.jmedchem.8b01757.

31. Selective Inhibition of Sialic Acid-Based Molecular Mimicry in Haemophilus Influenzae Abrogates Serum Resistance. Heise T., Langereis J.D*., Rossing E., de Jonge M.I., Adema G.J., Bull C., Boltje T.J*, Cell. Chem. Biol., 2018, 25, 1-7.


30. Direct experimental characterization of glycosyl cations by infrared ion spectroscopy. Elferink H., Severijnen M.E., Martens J., Mensink R.A., Berden G., Oomens J., Rutjes F.P.J.T., Rijs A.M.*, Boltje T.J.*, J. Am. Chem. Soc., 2018, 140, 6034-6038. 10.1021/jacs.8b01236.


29. Sialic acid blockade suppresses tumor growth by enahcning T cell-mediated tumor immunity. Bull C., Boltje T.J., Balneger N., Weicher S.M., van Gemst J.J., Bloemendal V.R.J.L., Boon L., van der Vlag J., Heise T., den Brok M.H., Adema G.J.*, Cancer Res. 2018, 10.1158/0008-5472.CAN-17-3376


28. Peptide-appended permethylated β-cyclodextrins with hydrophilic and hydrophobic spacers. Al Temimi A.H.K., Boltje T.J., Zollinger D., Rutjes F.P.J.T., and Feiters M.C.*, Bioconjugate Chem. 2017, 10.1021/acs.bioconjchem.7b00319.

27.  Advances in stereoselective glycosylation using chiral auxiliaries. R.A. Mensink and T.J. Boltje*, Chemistry a European Journal, 2017, 10.1002/chem.201700908


26.   Metabolic Oligosaccharide Engineering with Alkyne Sialic Acids Confers Neuraminidase Resistance and Inhibits Influenza Reproduction. T. Heise, C. Büll, D.M. Beurskens, E. Rossing, M.I. de Jonge, G.J. Adema, T.J. Boltje* and J.D. Langereis*, Bioconjugate Chem. 2017, 10.1021/acs.bioconjchem.7b00224.

TOC Bioconj chem

25.   Steering sialic acid-Siglec interactions of living cells using bioorthogonal chemistry. Christian Büll, Torben Heise, Niek van Hilten, Johan F.A. Pijnenborg, Victor Bloemendal, Lotte Gerrits, Esther D. Kers-Rebel, Tina Ritschel, Martijn H. den Brok, Gosse J. Adema* & Thomas J. Boltje *, Angewandte Chemie, 2017, 56, 3309-3313.


24.   Metabolic sialic acid blockade lowers the activation threshold of moDCs for TLR stimulation. Christian Büll, Estel Collado-Camps, Esther D Kers-Rebel, Torben Heise, Jonas N Søndergaard, Martijn H den Brok, Barbara M Schulte, Thomas J Boltje and Gosse J Adema* Immunology and Cell Biology, 2016, 95, 408-415, doi:10.1038/icb.2016.105.

23. A Study on Stereoselective Glycosylations via Sulfonium Ion Intermediates. Mensink R.A., Elferink H., White P.B. Pers, N., Rutjes F.P.J.T., and Boltje T.J.*; European Journal of Organic Chemistry. 2016, 27, 4656-4667.


22. Stereoselective beta-Mannosylation via Neighboring Group Participation.  Elferink H., Mensink R.A., White P.B. and Boltje T.J.*; Angewandte Chemie International Edition. 2016, 55, 37, 11217-11220, doi:10.1002/anie.201604358.


21. Bioengineered Kidney Tubules Efficiently Excrete Uremic Toxins. Jansen J., Fedecostante M., Wilmer M.J., Peters J.G., Kreuse U.M., van den Broek P.H., Mensink R.A., Boltje T.J., Stamatialis D., Wetzels J.F., van den Heuvel L.P., Hoenderop J.G., Masereeuw R.*. Scientific Reports, 2016, doi:10.1038/srep26715.

20. NANS-mediated synthesis of sialic acid is required for brain and skeletal development. C.D.M. van Karnebeek, L. Bonafé, X-Y. Wen, M.T. Graovac, S. Balzano, B. Royer-Bertrand, A. Ashikov, L. Garavelli, I. Mammi, L. Turolla, C. Breen, D. Donnai, V. Cormier, D. Heron, G. Nishimura, S. Uchikawa, B. Campos-Xavier, A. Rossi, T. Hennet, K. Brand-Arzamendi, J. Rozmus, K. Harshman, B.J. Stevenson, E. Girardi, G. Superti-Furga, T. Dewan, A. Collingridge, J. Halparin, C.J. Ross, M.I. Van Allen, A. Rossi, U.F. Engelke, L.A.J. Kluijtmans, E. van der Heeft, H. Renkema, A. de Brouwer, K. Huijben, F. Zijlstra, T. Heise, T.J. Boltje, W.W. Wasserman, C. Rivolta, S. Unger, D.J. Lefeber, R.A. Wevers & A. Superti-Furga; Nature Genetics 2016, doi:10.1038/ng.3578.

19. Sialic Acid Mimetics to Target the Sialic Acid-Siglec Axis. Büll C., Heise T., Adema G.J.*, Boltje T.J.*; Trends in Biochemical Science. 2016, vol 41, issue 6, 519-531,



18. Sialic Acid Glycoengineering Using an Unnatural Sialic Acid for the detection of Sialoglycan Biosynthesis Defects and On-Cell Synthesis of Siglec Ligands. Büll C., Heise T., Beurskens D.M.H., Riemersma M., Ashikov A., Rutjes F.P.J.T., van Kuppevelt T.H., Lefeber D.J., den Brok M.H., Adema G.J.*, Boltje T.J.*; Chem. Biol. 2015, 10, 2353-2363.


17. Targeted Delivery of a Sialic Acid-Blocking Glycomimetic to Cancer Cells Inhibits Metastatic Spread. Büll C, Boltje T.J., van Dinther E., Peters T., de Graaf A.M.A., Leusen J.H., Kreutz M., Figdor C.G., den Brok M.H., Adema G.J.*; ACS Nano. 2015, 9, 733-745.


16. Disease Mutations in CMP-Sialic Acid Transporter SLC35A1 Result in Abnormal a-dystroglycan O-Mannosylation, Independent from Sialic Acid. Riemersma M., Sandrock J., Boltje T.J., Büll C., Heise T., Ashikov A., Adema G.J., van Bokhoven J., Lefeber D.J.; Mol. Genet. 2015, 24, 2241-2246.



15. A Divergent Method to Prepare 5-Amino, 5-N-Acetamido and 5-N-Glycolyl Sialosides. Boltje T.J.*, Heise T., Rutjes F.P.J.T., van Delft F.L. J. Org. Chem. 2013, 24, 5257-5261.


14. Targeting Aberrant Sialylation in Cancer Cells Using A Fluorinated Sialic Acid Analogue Impairs Adhesion, Migration and In Vivo Tumor Growth. Büll C, Boltje T.J., Wassink M, de Graaf A.M.A, van Delft F.L., den Brok H., Adema G.J.*; Mol. Cancer Ther. 2013, 12, 1935-1946.



13. Chemical Synthesis and Immunological Evaluation of the Inner-Core Oligosaccharide of Francisella tularensis. Boltje T.J., Zhong W., Park J., Wolfert M.A., Wangxue C, and Boons G.J.*, Am. Chem. Soc. 2012, 134, 14255-14262.


12. The C-2 (S)-(phenylthiomethyl)benzyl Ether: A Highly Selective Chiral Auxiliary for the Stereoselective Synthesis of 1,2-cis Boltje T.J., Benedict R., Boons G.J.*, Carbohydrate Chemistry: Proven Methods, Volume 2, accepted for publication, Editors: Paul Kovac, Jeroen Codée and Gijsbert van der Marel.


11. Diphenylsulfoxide-Trifluoromethanesulfonic Anhydride: a Potent Activator for Thioglycosides. Codée J.D.C., Boltje T.J., van der Marel G.A.*, Carbohydrate Chemistry: Proven Methods, Volume 1, 2011, Editor: Paul Kovac.

10. Stereoelectronic Effects that Determine Oxa-carbenium vs b-Sulfonium Ion Mediated Glycosylation. Boltje T.J., Kim J-H., Park J., Boons G.J.*, Lett. 2011, 13, 284-287.


9. Metal Free Sequential [3+2]-Dipolar Cycloadditions using Cyclooctynes and 1,3-Dipoles of Different Reactivity. Sanders B.C., Friscourt F., Ledin P., Arumugam S., Guo J., Boltje T.J., Popik V., Boons G.J.*, Am. Chem. Soc, 2011, 133, 949-957.



8. Versatile Set of Orthogonal Protecting Groups for the Preparation of Highly Branched Oligosaccharides. Boltje T.J., Li. C., Boons, G.J.*, Org. Lett. 2010, 12, 4636-4639.


7. Chiral-auxiliary-mediated 1,2-cis-glycosylations for the solid-supported synthesis of a biologically important branched a-glucan. Boltje T.J., Kim. J-H., Park. J., Boons. G.J.*, Nature Chemistry. 2010, 2, 552-557.


6. Synthesis and Evaluation of Lipophilic Aza-C-glycosides as Inhibitor of Glucosylceramide Metabolism. T., van den Berg. R.J.B.H.N., Boltje. T.J., et. al. Eur. J. Org. Chem. 2010, 7, 1258-1283.



5. Opportunities and Challenges in Synthetic Oligosaccharide and Glycoconjugate Research. T.J., Buskas. T., Boons. G.J.*, Nature Chemistry. 2009, 1, 611-622.


4. Direct and Stereoselective Synthesis of Alpha-linked 2-Deoxyglycoside. J., Boltje. T.J., Boons. G.J.*, Org. Lett. 2008, 19, 4367-4370.



3. Synthetic Study Toward the PSA1 Tetrasaccharide Repeating Unit. Van den Bos. L.J., Boltje. T.J., Provoost. T., et. al. Letters. 2007, 48, 2697-2700.



2. An Efficient Synthesis of the Natural Tetrahydrofuran Pachastrissamine Starting from d-ribo-phytosphingosine. Van den Berg. R.J.B.H.N., Boltje. T.J., Verhagen C.P., et. al. Org. Chem. 2006, 71, 836-839.



1. Thioglycuronides: Synthesis an Application in the Assembly of Acidic Oligosaccharides. Van den Bos. L.J., Codee. J.D.C., van der Toorn. C., Boltje. T.J., et. al. Org. Lett. 2004, 13, 2165-2168.