I obtained my bachelor and master’s degree in chemistry from the Radboud University Nijmegen. During my bachelor internship I learned about carbohydrate chemistry in the Boltje research group and I became immediately intrigued by this field of research. During my masters I worked for over a year on sialic acid derivatives, a carbohydrate that is abundantly present on the outer cell membrane with vital functions in both health and disease [1,2]. Then I expanded my knowledge and skills in glycobiology in the group of prof. Carolyn Bertozzi at Stanford University for 5 months where I worked on antibody-sialidase conjugates. In January 2018 I started my PhD in the Boltje research group. Here I am working on new chemical tools for the study and perturbation of carbohydrate processing enzymes. Using these tools I hope to expand our knowledge in the field of glycobiology while also developing new potential therapeutics in cancer.
- Steering Siglec–Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry, C. Büll, T. Heise, N. van Hilten, J.F.A. Pijnenborg, V.R.L.J. Bloemendal, L. Gerrits, E.D. Kers-Rebel, T. Ritschel, M.H. den Brok, G.J. Adema, T.J. Boltje, Angew. Chem. Int. Ed. 2017, 56, 3309. https://doi.org/10.1002/anie.201612193
- Potent Metabolic Sialylation Inhibitors Based on C-5-Modified Fluorinated Sialic Acids, T. Heise*, J. F. A. Pijnenborg*, C. Büll, N. van Hilten, E.D. Kers-Rebel, N. Balneger, H. Elferink, G.J. Adema, T.J. Boltje, J. Med. Chem. 2019, 62, 2, 1014-1021. https://doi.org/10.1021/acs.jmedchem.8b01757 *Co-first authorship